Posts Tagged ‘advanced glycation end-products’

An alternative to vitamin D supplements?

Posted 11 Feb 2013 — by Todd
Category Diet, Fitness, Health, Hormesis

Screen Shot 2013-02-10 at 11.51.13 PMMy recent post on Why I don’t take vitamin D supplements generated a lot of interest and a few misconceptions.  In that article, I did not suggest any practical alternatives to taking high dose vitamin D supplements.  Here I will suggest a way that may provide the benefits of vitamin D without popping any pills, spending all day in the sun, or ingesting copious amounts of fish.

Some readers got the idea that I believe vitamin D is not beneficial, and that I discount the evidence from studies that show the benefits.  I want to dispel that notion.  I do acknowledge the key role that vitamin D and the vitamin D receptor (VDR) play in bone mineralization and regulation of  innate and adaptive immunity, and among other things.  I further acknowledge that many (but certainly not all) studies support an association between higher vitamin D3 levels and reduced incidence of diseases such as cancer.

As I wrote:

Nobody doubts the important role of vitamin D in the body. But are higher levels of a hormone like vitamin D–whether or not provided as a supplement– always a good thing?

My doubts are focused on several points:

  • Under-appreciation of the fact that vitamin D is a hormone with diverse and dose-dependent systemic effects, still not fully understood
  • Misleading  claims that vitamin D supplementation is “equivalent”  to vitamin D from sun exposure. While the two forms are chemically identical, levels of vitamin D3 synthesized from sun exposure are self-limiting due to feedback regulation.  What happens when we chronically exceed natural limits?
  • Inadequate attention to the possible effects of chronic vitamin D supplementation on homeostatic down-regulation of the VDR receptor. See this discussion bv Dr. David Agus of USC medical school.
  • Inadequate study of the possible long term adverse effects of chronic vitamin D supplementation. Few studies look beyond 4 years. Hormone replacement therapy was in favor for 50 years before the risks came to light . Things don’t necessarily look any more promising when synthetic hormones are replaced bioidentical hormones.

My article created a dilemma for several commenters. These people acknowledged the risks, but nevertheless cited  benefits they personally experienced  from supplementing with vitamin D–ranging from fewer colds and flu, to relief of autoimmune symptoms, and even lessening of depression.

For these people, a key question remains:

Is there a way to get the benefits of vitamin D supplementation, while avoiding the dependency and risks of taking vitamin D capsules daily for the rest of your life?  While I don’t have a definitive proven answer to that question, recent research leads me to speculate here that there is a promising approach that is within everyone’s reach.

It lies within a powerful natural biological process called autophagy.

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